Cambridge Isotope Laboratories
TEWKSBURY, Mass., Sept. 26, 2022 (GLOBE NEWSWIRE) — Cambridge Isotope Laboratories, Inc. (CIL) has partnered with ISOtopic Solutions to bring the new stable isotope labeled and unlabeled crude lipid yeast extracts to market bring to. These were designed to provide hundreds of fatty acids and lipids for use in MS lipidomics research and development.
Andrew Percy (Ph.D.), MS’ Omics Product Manager and Senior Applications Scientist for Mass Spectrometry at CIL, explains: “These analytes are broadly distributed across a variety of metabolic classes and pathways, and standards that are commercially available in a single mixture for the targeted Profiling and relative quantification of the lipidome are available.”
Andrew continues, “A major advantage of the stable isotope labeled lipid yeast extract is that the fatty acids and lipids are uniform 13C-labeled at high isotopic enrichment. 13C-labeling offers superior isotopic stability and analytical reliability compared to 2H (or deuterium) designation.”
Gerrit Hermann (Ph.D.), Founder and CEO of ISOtopic Solutions, explains: “Until now, the lack of suitable internal standards has been one of the biggest limiting factors to achieve absolute quantification in the field of lipidomics. Internal standards are a prerequisite to achieve a to ensure high precision and accuracy and to correct errors introduced during sample preparation procedures. However, due to the high number and structural diversity of lipid molecules, it is almost impossible to ensure molecule-specific stable isotope-labeled internal standardization, which explains why class-specific internal standards were used.13C-labelled lipid yeast extract could make it possible to overcome these deficiencies. In fact, these U13C-labelled yeast cell extracts have already been used extensively in microbiological metabolism studies, including targeted quantitative metabolite profiling.”
Overall, these lipid-yeast extract blends (Cat # L-ISO1 and L-ISO1-UNL) are well suited for researchers performing MS lipidomics and integrative MS omics (including lipidomics). Both products are exclusively available through CIL. To learn more about these new crude lipid yeast extracts, as well as the established metabolite yeast extracts (Cat # ISO1 and ISO1-UNL), please visit isotop.com.
About Cambridge Isotope Laboratories, Inc.
CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED and industrial applications. CIL is an operating company owned by Otsuka Pharmaceuticals. The CIL business consists of two facilities in the Boston area of MA; a large isotopic enrichment manufacturing facility in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and eurisotope in Saclay, France. For more information on CIL, see isotop.com.
About isotopic solutions
ISOtopic Solutions was founded as an analytical-biotechnological university spin-off from the University of Vienna. The ISOtopic Solutions product line consists of stable isotope labeled biomolecules and labeled biomass for the standardization and validation of mass spectrometric analysis methods. As a clear mission statement, ISOtopic Solutions intends to advance the scientific field by providing effective solutions for scientists and people working in the field of analytical chemistry. For more information visit isotopic-solutions.com.
Figure 1: Cambridge Isotope Laboratories
Cambridge Isotope Laboratories
Figure 2: ISOtopic solutions
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